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Although neurons activate compensatory NAD + salvage through nicotinamide phosphoribosyltransferase (NAMPT) [108], this pathway fails to offset PARP-1-driven NAD + catabolism during stroke [106], resulting in sustained sirtuin suppression and disrupted mitochondrial dynamics

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Bloemendal H, De Jong W, Jaenicke R, Lubsen NH, Slingsby C, Tardieu A

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