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Description
Chlorogenic acid ameliorates isoproterenol-induced myocardial injury in rats by stabilizing mitochondrial and lysosomal enzymes
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Addition of the Proteasome-Glo Cell-Based Reagent in an "add-mix-measure" format results in proteasome cleavage of the substrate and rapid generation of a luminescent signal produced by the luciferase reaction
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Furthermore, disrupted calcium oscillations amplify energy crises: while physiological oscillations optimize TCA cycle efficiency via pyruvate dehydrogenase phosphatase activation, sustained pathological calcium signaling uncouples ATP synthesis from oxidative phosphorylation, accelerating cardiomyocyte apoptosis [81]
