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It is available in liquid form and can be applied directly to hemorrhoids

But it is worth being precise: these are proposed and studied mechanisms, not settled clinical facts

Ferr S (2008) An update on the mechanisms of the psychostimulant effects of caffeine

Over the past few decades, advances in peptide synthesis, modification, and delivery have transformed peptides into a major drug class used in endocrinology, oncology, metabolism, and autoimmune disease

doi: 10.3390/cimb45080420