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TNF- and IL-17A-mediated S100A8 expression is regulated by p38 MAPK

A 2024 trial found a cream with 5% alpha-arbutin and 2% kojic acid worked about as well as a prescription melasma cream but with fewer side effects

& Cohen, G

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Together, these two ( TB-500 and BPC-157) improve motility, structural reorganization, growth factors, and cytoprotection