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In the nucleus, Nrf2 binds to antioxidant response element (ARE) and triggers the transcription of numerous antioxidation-related genes, including NAD(P)H quinone dehydrogenase 1 (NQO1), Heme oxygenase-1 (HO-1), and glutathione peroxidase (GPx) (Yu and Xiao, 2021)

Furthermore, exploring the underlying mechanisms in more depth will enhance our understanding of how aerobic exercise influences cognitive outcomes and may lead to the identification of key biomarkers that can predict individual responses

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