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But BPC-157
, exosomes derived from MSCs increase the proliferation and migration of chondrocytes in vitro , and exert notable therapeutic effects in a collagenase-induced osteoarthritis mouse model [75], while exosome-laden hydrogels can drive cartilage regeneration in a rabbit model of cartilage defect [76]
A VEGFR targeting peptide-drug conjugate (PDC) suppresses tumor angiogenesis in a TACE model for hepatocellular carcinoma therapy
Almost all the proteins in living organisms are composed of L-type amino-acids, but the spatial conformation of D-type structure does not match the natural receptors, which can effectively avoid being recognized by immune system, thereby avoiding the activation of pro-inflammatory signaling pathways 54,55
doi:10.1158/1535-7163.MCT-14-0144
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