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The Myc oncogene family is under the regulation of BRD4, and there have been numerous in vitro and in vivo studies showing the effectiveness of BET inhibitor (BETi) against Myc-driven cancers.88, 89, 90, 91, 92 Recently, a phase 1 and 2 clinical trial was completed to study the optimal dosing for the BETi molibresib in patients with solid tumors, including NSCLCs and SCLCs

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