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Cell (2018) 175(3):67994 e22

Choi BK, Lee DY, Lee DG, Kim YH, Kim SH, Oh HS, et al

3, 2007 Accessed Dec 3., 2007 See especially discussion on activated charcoal column purification for the origin of this compound

UV exposure, pollution, and inflammation all increase MMP activity, accelerating collagen destruction beyond normal aging rates

Overall, it would appear that the abundance of GSTs and their predominantly high activity with JS-K would cause the rapid biotransformation of the prodrug in most tissues