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Interestingly, the generation of R-2-HG from glutamine has been proven to occur rapidly in patient-derived chondrosarcoma cell lines harboring endogenous IDH mutations, indicating fundamental metabolic differences between cells that harbor IDH1/2 mutations and those that do not 121

Joint health : Glutathione eases joint stiffness due to normal daily exercise and activity by promoting the functions of joint and connective tissue

Its quite possible the trial will conclude sometime in 2023, with data to follow