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Description
Over the past decade, gemcitabine has remained the standard first-line therapy for advanced PDAC, primarily exerting its effects by inducing DNA damage, promoting ROS accumulation, and triggering ferroptosis [153]
Biological age is calculated organ by organ using DNA methylation clocks (Horvath clock methodology)
102 , e42 (2021)
Food and Drug Administration, 2023a)
doi: 10.1073/pnas.2221047120 76 WolfC.HochgrfeF.KuschH.AlbrechtD.HeckerM.EngelmannS
