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Description
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doi: 10.2147/COPD.S348569 11 WanAChenD

Under moderate ROS formation, apoptosis can start with the activation of pro-apoptotic factors, i.e., JNK, and inhibition of pro-survival factor, i.e., NF-kB, without changing the redox status of the caspases

Prevents glutathione depletion within liver cells, supporting detoxification and protecting cells from free radical activity

The protein apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/REF-1) negatively regulates Nrf2 through its redox activity, with inhibition of APE1/REF-1 causing significant increases in the levels of Nrf2 and selected target genes HMOX1, GCLC , and GCLM in pancreatic cancer cell lines without causing the generation of ROS [323]
