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[DOI] [PubMed] [Google Scholar] 17.Neelakantan H, Wang HY, Vance V, Hommel JD, McHardy SF, Watowich SJ

Nasal spray provides systemic distribution that may dilute effects at a specific location

Thus, passive diffusion of peptides is very limited unless the peptides possess an amphipathic structure or use synthetic means to modify the lipophilicity [2,6], such as the glycosylation strategy of peptides [12]

Larazotide (intestinal health) Article: Larazotide: potential for intestinal health Larazotide is a synthetic peptide that shows promise for strengthening intestinal tight junctions to prevent leaky gut syndrome, reducing passage of toxins, bacteria, and undigested food into the bloodstream that triggers inflammation and autoimmune responses

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