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Deleterious reactive metabolites like ROS have a harmful role in inducing DNA mutations, epigenetic alterations, post-translational modifications of protein kinase (cysteine residues)[10], lipid peroxidation, and other key cellular components irreversible damage to these cells, thereby reprogramming their metabolic pathways of development, proliferation, activation and function, ultimately giving rise to psoriasis [15, 26, 27]

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