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Previous researches demonstrated that the reduction of melatonin levels in CSF and serum leads to the aggravation of AD neuropathology [37, 38, 63]

Low-Molecular Collagen Peptide Supplementation and Body Fat Mass in Adults Aged 50 Years: A Randomized, Double-Blind, Placebo-Controlled Trial
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It is possible that, by interrupting the production of glutamine and glutamate, the risk C allele makes people more susceptible to oxidative stress, particularly the oxidative stress caused by high blood sugar levels (as seen in Type II diabetes)