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Physiological Function of NNMT and the Related Metabolic Pathways NNMT is a cytosolic enzyme that catalyzes NA methylation using S-adenosyl-methionine (SAM) as a methyl donor, while producing 1-methylnicotinamide (MNA) and S-adenosyl-homocysteine (SAH)

Our present results indicate that treatment with a heavy-chain anti-CD38 antibody selectively targeting the ectoenzyme domain, but not with an anti-CD38 antibody that does not block ectoenzyme, prevented bleomycin-induced weight loss, skin fibrosis and architectural remodeling in the lung, accompanied by reduced collagen deposition and significant improvement of pulmonary functions

It has one of the most complex structures of all vitamins

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