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As only one of two glycolytic enzymes that generates ATP, homozygous or compound heterozygous loss-of-function mutations in the PKLR gene, which encodes erythrocyte PK, result in erythrocyte ATP shortage

Powell WS, Rokach J

In the epididymis, oxidative stress and disturbed pH/ion homeostasis (HCO3/Ca2+) alter the transport and delivery of protein/RNA cargo in epididymosomes, interfering with terminal sperm maturation

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