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Found mixed results, showing that outcomes depend on strict patient selection with diagnostic medial branch blocks

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Feature Injection Oral Supplement Absorption Rate Near 100% Variable (3070%) Works with gut issues Yes No Speed of level increase Days to weeks Weeks to months Daily pill burden None Daily Clinically supervised dose Yes Self-managed Suitable for severe deficiency Preferred Often insufficient

One study reported that vitamin B12 deficiency was associated with twice the risk of severe depression (4)

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