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Notably, N259 and E255 in the C1 region are critical residues

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The bioactive compounds present in green coffee, not only chlorogenic acids and their derivatives, but also caffeine, theophylline, and theobromine, cafestol, kahweol, tocopherols and trigonelline [13, 14]

Consequently, it is plausible that, in our system, autophagy induction could be related to redox unbalance caused by defects in cell metabolism