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The calvariectomy procedure included, medially to the superior temporal lines and temporalis muscle attachments, 6 burr holes drilled in three horizontal lines (just basal from the posterior interocular line (two rostral burr holes), just rostral to the lambdoid suture (and transverse sinuses) on both sides (two basal burr holes) and in line between the basal and rostral burr holes (two middle burr holes))

Upon sample injection, solute molecules will exchange with the buffer ions as each competes for the binding sites on the resin

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Larrey D, Pageaux GP

doi: 10.1016/j.survophthal.2017.10.007