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469 In another phase 2 trial, the combination of AR inhibitor and ICI showed a modest clinical benefit rate of 25% at 16 weeks in heavily pretreated AR-positive TNBC without preselected PD-L1

Efficacy and safety of multi-target therapy in children with lupus nephritis

Interestingly, kynurenine and xanthurenic acid produced by the TDO-dependent kynurenine pathway can drive AhR activity in TNBC cells