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Description
484 NDDs include diseases such as AD, PD, Huntingtons disease (HD), and ALS, which are characterized by a progressive dysfunction and loss of neurons in specific brain regions, leading to symptoms such as cognitive and motor deficits (e.g., dementia and tremors)

Although multiple metabolic routes have been shown to be affected in NF1 tumorigenesis, metabolic based anti-neoplastic approaches are limited in the field (BeGIN clinical trial) and others are at the preclinical stage (Figure 3)

Depletion of glutathione affects root development also by interfering with auxin transport 84,89,90

Figure 4 and Supplementary Figs S2 and S3 illustrate the endpoint morphology of the cells under each of the 4 conditions described above
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