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In patients with diabetes and albuminuria, the HRs for MACE, HHF, and CKD progression with triple combination therapy were estimated to be 0.65 (95% CI 0.550.76), 0.45 (95% CI 0.340.58), and 0.42 (95% CI 0.310.56), respectively, compared with those for conventional therapy alone (renin-angiotensin system inhibitors and classical risk factor management)

Shock and multiple organ failure

The Trx system plays a key role in DNA synthesis, anti-apoptotic signaling, and regulation of redox-sensitive transcription factors

The treatment protocol involved weekly injections for 4-7 weeks, suggesting that tissue regeneration effects require sustained exposure over multiple weeks

98 SebecicB.NikolicV.SikiricP.SeiwerthS.SosaT.PatrljL.et al (1999)