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The rate constants from our deglutathionylation assays between 6.4 10 4 and 1.4 10 6 M 1 s 1 are very similar to the rate constants for PfGrx or plant and mammalian glutaredoxins from discontinuous or coupled enzymatic assays with other high and low molecular weight GSSR substrates (Table 1) 9,11,14,19 , thus confirming our assay as an alternative reliable method for the direct analysis of enzyme-catalyzed deglutathionylations

A pooled analysis of 1,298 ME/CFS patients from eight trials revealed that CBT was associated with significant reductions in fatigue severity and functional impairment, alongside improvements in physical function [160]

Participants with hepatic impairment were allocated into three groups, with the degree of impairment categorised by the investigator according to ChildPugh criteria: mild (Grade A

N., Chen, X., Dobrovolskaia, M

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