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Cell 31 , 6778 (2008)

Moderate overexpression of Drosophila ULK1 prolonged lifespan, but ULK1 overexpression inhibited mitochondrial metabolism and led to progressive lipid damage and shortened lifespan [178]

I believe some of these concepts are extremely positive (woot, meditation!) and others to be downright dangerous (yes, coffee enemas are a good example), and of course, theres the entire world of gray in between

Nearly 70% of genes upregulated in Sf1-Cre high KO male adrenals belong to the list of upregulated genes in ARKO male adrenals, and 55% belonged to the list of downregulated genes (Fig